乳腺癌中的心脏健康 (CHiB):单中心随机对照试验的协议
Hannes Colditz1, Lynn Matits1,2, Johannes Kersten1
1Sports and Rehabilitation Medicine, Ulm University Hospital, Ulm, Baden-Württemberg, Germany.
BMJ open sport & exercise medicine
|November 6, 2024
概括
在接受心脏毒性治疗的乳腺癌患者中,结构化的运动可以预防心脏功能障碍. 这项研究探讨了炼运动.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 运动生理学 运动生理学
背景情况:
- 乳腺癌发病率和生存率的增加导致更多患者经历长期治疗副作用.
- 与癌症治疗相关的心脏功能障碍 (CTRCD) 是一个重要的关注,没有确立的初级预防措施.
- 更长的存活期需要策略来减轻治疗引起的心脏损伤.
研究的目的:
- 研究结构化炼计划对接受心脏毒性治疗的乳腺癌患者心脏变化的影响.
- 为了确定运动是否可以减轻症状或无症状CTRCD的发生.
- 评估二次终点,包括心脏炎症,线粒体功能,生活质量和运动能力.
主要方法:
- 一个双臂,单中心,随机对照试验,涉及48名女性乳腺癌患者.
- 干预组 (IG):6个月的监督高强度间歇训练 (HIIT) 和高强度抵抗训练 (HIRT).
- 控制组 (CG):独立遵循世卫组织的体力活动指南.
- 在基线,6个月和12个月进行心脏评估 (心声图,CMR,心肺运动测试).
主要成果:
- 主要终点:在指定的时间点通过心脏成像检测到的CTRCD的发生.
- 二级终点:心脏炎症 (CMR),线粒体功能障碍,生活质量,疲劳,抑郁,焦虑,运动能力,心率指标和日常身体活动.
结论:
- 这项研究旨在提供结构化体育炼作为乳腺癌患者中CTRCD的主要预防策略的证据.
- 研究结果将为在癌症治疗期间和之后管理心脏健康的临床指南提供信息.
- 这项研究解决了对乳腺癌患者的生存护理的关键未满足需求.
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