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乳腺癌化学预防纳米生 officinale 罗斯科

Andika Pramudya Wardana¹, Alfinda Novi Kristanti^2,3, Nanik Siti Aminah^2,3

¹Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Surabaya, Surabaya, East Java, Indonesia.

International journal of nanomedicine

|November 6, 2024

概括

纳米封装生提取物 (Zo-NPs) 在小鼠中显示出对乳腺癌的化学预防作用. Zo-NPs保护了乳腺组织,改善了抗氧化剂水平,提供了一个有前途的自然治疗策略.

科学领域:

生物医学科学生物医学科学
药理学药理学是指药理学的学科.
自然产品化学自然产品化学

背景情况:

癌症,特别是乳腺癌,是全球主要的死亡原因,由不受控制的细胞增殖驱动.
辛格贝尔的官员是罗斯科. (生) 具有具有抗氧化特性的化合物,表明潜在的治疗应用.
开发新的化学预防策略对于有效打击癌症至关重要.

研究的目的:

为了研究纳米封装Zingiber officinale Roscoe的体内化学预防潜力. (Zo-NPs) 对抗化学诱导的乳腺癌.
评估Zo-NPs在预防乳腺组织组织学变化的有效性.
评估Zo-NP对关键抗氧化和炎症生物标志物的影响.

主要方法:

雌性Mus musculus Balb/c小鼠被诱导使用佐[α]烯来模拟乳腺癌.
卡拉基南封装的生树 officinale Roscoe 的化学预防作用. (Zo-NPs) 进行了评估.
进行了乳腺组织的组织学分析和测量血清抗氧化酶 (CAT,GSH,SOD) 和TNF-α水平.

主要成果:

纳米封装的生 officinale 罗斯科. 提取物产生了Zo-NP,颗粒大小为483.30±11.23nm,表现出稳定性.
施用Zo-NPs可以防止本佐[α]烯诱导的乳腺扩张和乳腺组织的组织学变化.
与未封装的提取物相比,Zo-NPs显著增加了抗氧化酶 (CAT,GSH,SOD) 的血清水平,并更有效地降低了TNF-α水平.

结论:

纳米封装Zingiber官网罗斯科. 在小鼠模型中显示出显著的体内化疗预防性抗乳腺癌的有效性.
Zo-NPs对乳腺组织提供保护作用,并增强身体的抗氧化剂防御系统.
这些发现突显了Zo-NPs作为乳腺癌化学预防的有前途的天然剂的潜力.

关键词:

辛吉伯官员罗斯科罗斯科罗斯科乳腺癌乳腺癌乳腺癌化学预防性药物这是一种纳米封装.红色的生红色的生.

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