在美国退伍军人中加速表观遗传衰老和潜在的发病率和死亡率
Kyle J Bourassa1,2,3,4, Livia Anderson5, Sandra Woolson5
1VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System.
medRxiv : the preprint server for health sciences
|November 6, 2024
概括
用DunedinPACE分数衡量的加速表观遗传衰老与退伍军人的慢性疾病增加和更高的医疗保健成本有关. 这项研究验证了表观遗传衰老作为未来健康结果和死亡率的预测因素.
科学领域:
- 生物标志物 生物标志物
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
背景情况:
- 基因甲基化为衰老,发病率和死亡率提供了有希望的生物标志物.
- 在现实世界的临床环境中验证对于表观遗传衰老措施至关重要.
- 杜内丁PACE是一种源自DNA甲基化而产生的表观遗传衰老评分.
研究的目的:
- 调查加速的DunedinPACE衰老得分与慢性疾病发病率之间的关联.
- 为了确定DunedinPACE分数是否能预测医疗保健成本和死亡率.
- 用电子健康记录在现实世界医疗保健系统中验证表观遗传衰老.
主要方法:
- 利用了来自2,216名9/11后退伍军人的数据.
- 评估了DunedinPACE的衰老得分及其与慢性疾病的关联.
- 分析了医疗保健成本和死亡率,平均随访时间为13.1年.
- 使用VA电子健康记录进行数据提取.
主要成果:
- 更快的DunedinPACE衰老得分与慢性疾病发展的增加相关.
- 加快的老龄化预测在5,10和15年内医疗保健成本会更高.
- 快速衰老与发生的心肌梗塞,中风,糖尿病,癌症,肝病和病有关.
- 加快表观遗传衰老增加了所有原因和慢性疾病死亡率的风险.
结论:
- 加速表观遗传衰老是健康状况恶化的重要预测因素.
- 宁PACE分数在预测发病率和死亡率方面显示出临床有用性.
- 这些发现支持在综合医疗保健系统中使用表观遗传衰老进行风险评估.
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