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Jiemin Ma¹, Roman Groisberg¹, Changxia Shao¹

¹Merck & Co., Inc., Rahway, New Jersey, USA.

|November 6, 2024

概括

估计无差异性多形肉瘤 (UPS) 发病率是具有挑战性的,因为各种定义和缺乏特定的代码. 然而,在2000年至2020年期间,UPS的发生率有所下降.

科学领域:

在瘤学瘤学.
肉瘤研究研究肉瘤研究
癌症流行病学癌症流行病学

背景情况:

不分化形肉瘤 (UPS) 的分类随着免疫组织化学和基因组分析等诊断技术的进步而发展.
目前关于无差异化多形肉瘤 (UPS) 发生率的数据有限.
监测,流行病学和最终结果 (SEERs) 计划缺乏UPS的特定组织学代码,使发病率跟踪复杂化.

研究的目的:

为了估计在美国不分化的多形肉瘤 (UPS) 的发病率.
分析2000年至2020年UPS发生率的趋势.
突出需要改善UPS的诊断和分类准则.

主要方法:

在2000年至2020年期间,利用了SEERs计划中的22个注册表的数据.
根据临床专业知识,使用三个不同的定义估计UPS发生率.
分析了不同定义和时间段的发病率.

主要成果:

根据使用的定义,UPS发病率估计有很大差异,在2016-2020年每10万人中从0.06到0.67不等.
尽管定义有变化,但从2000年到2020年,UPS发生率的持续下降被观察到.
发病率的广泛范围强调了精确的UPS诊断和分类所面临的挑战.

结论:

由于缺乏标准化的诊断代码和不同的分类标准,无法准确估计UPS发生率.
在过去的二十年中,UPS发生率的下降趋势被注意到.
在美国,加强对UPS诊断和分类的标准化指南的实施至关重要.

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