与非滴水模式相关的生物标志物在2型糖尿病患者中与高血压相关
Viorel Manea1, Daniel-Corneliu Leucuţa2, Călin Pop1,3
1Department of Cardiology, "Constantin Opriş" Emergency County Clinical Hospital, Baia Mare, Romania.
Medicine and pharmacy reports
|November 6, 2024
概括
在2型糖尿病和高血压中,非浸泡式血压模式与糟糕的结果有关. 甘油三和葡萄糖的比率有效地区分了浸泡剂和非浸泡剂,有助于风险分层.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 临床生物标志物 临床生物标志物
背景情况:
- 非滴血血压模式影响大约50%的2型糖尿病 (T2D) 和高血压患者.
- 这种模式与心血管并发症增加和预后较差有关.
研究的目的:
- 为了确定简单的生物标志物来分类Dipper和非Dipper个体与T2D和高血压.
- 评估这些生物标志物的区分能力.
主要方法:
- 138名患有T2D和高血压的患者接受了24小时的门诊血压监测 (ABPM).
- 血液样本被分析为全血细胞计 (CBC) 和各种生物标志物.
- 接收器运行特征曲线 (AUC) 下的面积被用来评估生物标志物的性能.
主要成果:
- 甘油三与血红蛋白A1c (HbA1c) 的比率和甘油三与葡萄糖的比率是统计学上显著的差异化因素.
- 与非浸泡者相比,浸泡者对两个显著比率都有更高的值.
- 三甘油与葡萄糖的比率显示出最高的区分能力 (AUC = 0.774).
结论:
- 甘油三和葡萄糖的比率是一个有前途的,简单的生物标志物,用于对T2D和高血压患者的Dipper和Non-Dipper状态进行分类.
- 这种生物标志物具有风险分层和个性化治疗策略的潜力.
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