酸生物活性玻璃协同低剂量抗生素加载的植入物通过ATP破坏和氧化应激来对抗细菌,以顺序实现骨质整合

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Mengke Fan^1,2, Youliang Ren^3,4, Yanbin Zhu¹

¹Department of Orthopaedic Surgery the Hebei Medical University Third Hospital, Orthopaedic Research Institution of Hebei Province, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment of Ministry of Education, Key Laboratory of Biomechanics of Hebei Province, No.139 Ziqiang Road, Shijiazhuang, 050051, PR China.

Bioactive materials

|November 6, 2024

概括

这项研究将生物活性玻璃引入抗生素骨中,以对抗骨髓炎. 这种新材料有效杀死细菌,促进骨愈合,减少与高剂量抗生素相关的风险.

科学领域:

生物材料科学生物材料科学
整形外科手术整形外科手术
传染性疾病传染性疾病

背景情况:

使用带有抗生素的聚甲基甲基酸 (PMMA) 水泥治疗骨髓炎,面临着诸如对生物膜的低效,抗生素耐药性和毒性风险等挑战.
在植入物中的高剂量抗生素可以损害局部组织愈合,并促进细菌耐药性.

研究的目的:

开发一种智能策略,使用酸盐生物活性玻璃 (BSG) 融入低剂量 gentamicin 硫酸盐 (GS) 装载的 PMMA 水泥中.
为了协同消灭细菌,并顺序促进骨质整合,同时最大限度地减少与抗生素相关的风险.

主要方法:

将BSG纳入装有GS的PMMA水泥中.
评估水泥对细菌细胞壁,膜,ATP合成和活性氧物种 (ROS) 水平的影响.
对生物膜的抗菌活性和促进人类骨髓干细胞 (hBMSCs) 的骨质原生活性的评估 in vitro 和 in vivo 的骨质整合.

主要成果:

BSG创造了一个离子和性微环境,破坏了细菌细胞的完整性,并抑制了细菌的新陈代谢.
BSG协同增强了低剂量GS的抗菌作用,从而有效杀死细菌和清除生物膜.
植入物微环境和释放的GS促进了hBMSC的骨质活动,并增强了骨质整合.

结论:

将BSG纳入PMMA水泥是一种有前途的策略,可以减少骨髓炎治疗的抗生素剂量.
这种方法增强了抗菌活性和骨质生成,有可能解决细菌耐药性和骨感染之间的冲突.
开发的材料在骨科应用中提供了感染控制和改善骨愈合的双重好处.

关键词:

生物膜是一种生物膜.酸生物活性玻璃的玻璃.骨髓炎是一种骨质炎.聚甲基甲基酸聚甲基甲基酸黄金葡萄球菌黄金葡萄球菌

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