母亲血型是土耳其儿童患有唐氏综合征的先天性心脏病发展的可能预测因素
Yasar Kandur1, Derya Beyza Sayın Kocakap2, Aysegul Alpcan1
1Department of Pediatrics, School of Medicine, Kirikkale University, Kirikkale, Türkiye.
Journal of pediatric genetics
|November 6, 2024
概括
母亲血型A是唐氏症先天性心脏缺陷 (CHD) 的重要危险因素.
科学领域:
- 儿科 儿科 儿科
- 遗传学 是一个遗传学.
- 临床医学 临床医学
背景情况:
- 唐氏综合征 (DS),以三形21为特征,与各种临床异常有关.
- 先天性心脏缺陷 (CHD) 和甲状腺功能低下症是DS患者常见的并发症.
- 了解这些异常的风险因素对于早期干预和管理至关重要.
研究的目的:
- 评估唐氏综合征患者异常的临床特征和风险因素.
- 调查母亲和患者血型与这些异常之间的关联.
- 在DS中确定先天性心脏缺陷和甲状腺功能低下症的特定危险因素.
主要方法:
- 在2010年至2022年期间,对48名被诊断患有21型三形的儿科患者的病历进行了回顾性审查.
- 分析临床特征,包括先天性心脏病和甲状腺功能低下症.
- 统计分析,包括二进制后勤回归,以确定风险因素,重点关注母亲的血型和父亲的晚年.
主要成果:
- 在50%的DS患者中诊断出先天性心脏病 (CHD),心室隔膜缺陷和心房隔膜缺陷是最常见的.
- 甲状腺功能低下症在43.75%的患者中存在.
- 母亲血型A与较高的心脏病发病率 (63.6%对21.1%,p=0.020) 有显著的关联,并被确定为危险因素 (OR=6.563,p=0.025).
- 晚年父亲的年龄没有被发现是甲状腺功能低下症的危险因素.
结论:
- 母亲血型A是唐氏综合征患者先天性心脏缺陷的重要危险因素.
- 在母亲血型A的DS患者中,可能需要对心血管疾病进行早期查.
- 需要进一步的研究,以阐明将母体A型血液与DS中心血管疾病联系在一起的机制.
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