在修改后增强玉米丝聚糖的抗氧化和抗炎活性
Yu-Yun Zheng1, Xin-Yi Tong1, Da-Ying Zhang1
1Institute of Biomineralization and Lithiasis Research, College of Chemistry and Materials Science; Jinan University, Guangzhou, 510632, People's Republic of China.
Journal of inflammation research
|November 6, 2024
概括
的修饰显著提高了玉米丝多糖体 (Se-DCSP) 的生物活性. Se-DCSP表现出优异的抗氧化和抗炎作用,可以更好地保护细胞受损.
科学领域:
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 玉米丝多糖化物 (CSP) 具有潜在的生物活性.
- 修改天然的多糖类可以增强它们的功能性质.
- 以其抗氧化特性而闻名.
研究的目的:
- 为了研究修饰对玉米丝多糖的生物活性的影响.
- 评估化玉米丝聚糖 (Se-DCSP) 的抗氧化和抗炎作用.
- 评估Se-DCSP对细胞损伤的保护潜力.
主要方法:
- 降解的玉米丝多糖化物 (DCSP) 用HNO3-NaSeO3.3进行化.
- 对DCSP和Se-DCSP的表征包括ICP-AES,FTIR,UV-Vis,NMR,SEM和TGA.
- 通过显微镜和流细胞计,对HK-2细胞的保护作用和炎症因子变化进行了评估.
主要成果:
- 与DCSP相比,Se-DCSP的含量显著增加.
- Se-DCSP表现出增强的自由基清除 (2-3倍),减少细胞内活性氧物种 (1.5倍),并改善了线粒体膜潜力 (2.5倍).
- 在HK-2细胞中,Se-DCSP显著降低了炎症因子MCP-1 (1.7倍),NLRP3和NO (1.5倍).
结论:
- 修饰大大提高了玉米丝多糖的抗氧化和抗炎活性.
- Se-DCSP为细胞提供了对氧化应激的优越保护.
- Se-DCSP在抑制结石形成方面显示出有前途的潜力.
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