肝细胞癌风险预测和早期检测与代谢功能障碍相关的脂肪性肝病患者
Jeff Liang1, Naomy Kim2, Ju Dong Yang2,3,4
1Department of Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Translational gastroenterology and hepatology
|November 6, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 和MASH会增加肝癌的风险. 目前的监测不足,需要改善MASLD/MASH患者的风险分层和早期检测方法.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和其渐进的形式,MASLD (MASH),在全球范围内越来越普遍.
- MASLD/MASH显著增加肝细胞癌 (HCC) 的风险,这是癌症死亡的主要原因.
- 目前的HCC监测策略对于MASLD/MASH患者来说是不够的,特别是那些没有肝硬化的人.
研究的目的:
- 审查目前在MASLD/MASH患者中的HCC监测实践.
- 发现现有监督指南中的缺陷.
- 突出需要改进风险分层和诊断工具,以便早期检测HCC.
主要方法:
- 对2000年至2023年间发表的研究进行了全面的文献综述.
- 在MASLD/MASH患者中分析HCC的风险因素.
- 评估新型诊断和风险分层技术.
主要成果:
- 人口统计学,并发病,肝纤维化和遗传标记是HCC风险分层的关键因素.
- 对肝纤维化的非侵入性测试可以提高HCC风险评估和诊断.
- 机器学习和液体活检等新兴技术显示出早期HCC检测的潜力.
结论:
- 综合多种风险因素对于优化在不断增长的MASLD/MASH群体中早期检测HCC至关重要.
- 新的方法,包括非侵入性测试和先进的分子技术,是有希望的.
- 需要进一步的研究来验证和在临床实践中实施这些方法.
关键词:
与代谢功能障碍相关的脂肪性肝病 (MASLD)肝细胞癌 (HCC) 是一种肝细胞癌.与代谢功能障碍相关的脂肪肝炎 (MASH)非酒精性脂肪肝疾病 (NAFLD) 是一种非酒精性脂肪肝疾病.非酒精性脂肪肝炎 (NASH) 是一种非酒精性脂肪肝炎.更多相关视频
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
788
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.1K
相关概念视频
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
80
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
80
01:24Overview of Lipid Metabolism
1.0K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.0K