基于螺旋藻蛋白的新型功能载体用于提供黄素,其稳定性和抗氧化效率得到改善
Tian Xu1, Ling Yan1, Changhong Liu1
1School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China; Engineering Research Center of Bio-Process, Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.
Food chemistry
|November 6, 2024
概括
可持续采购的螺旋藻蛋白纳米颗粒 (SPNP) 有效封装黄素 (Cur),增强其抗氧化活性和稳定性. 这些SPNP提供了改善的营养药物化合物的传递,表明螺旋蛋白作为功能载体的潜力.
科学领域:
- 食品科学 食品科学 食品科学
- 营养保健品 营养保健品
- 生物材料是一种生物材料.
背景情况:
- 黄素 (Cur) 具有有益的抗氧化特性,但其稳定性和生物可用性不佳.
- 开发有效的输送系统对于增强Cur的治疗潜力至关重要.
- 螺旋藻蛋白 (SP) 为封装提供了一个可持续和潜在的功能来源.
研究的目的:
- 研究螺旋藻蛋白 (SP) 和其纳米粒子 (SPNP) 作为黄素 (Cur) 的载体.
- 评估Cur载SP和SPNP的封装效率,稳定性,抗氧化活性和生物可访问性.
- 探索SPNP作为营养药物增强输送系统的潜力.
主要方法:
- 使用加热凝和超声处理制备了SP纳米粒子 (SPNP).
- 分析了黄素封装效率,抗氧化活性,稳定性 (热,紫外线) 和体外消化.
- 进行了SP和SPNP作为Cur载体之间的比较分析.
主要成果:
- 与SP相比,SPNP表现出更高的疏水性和增强的抗氧化能力.
- 与SP相比,SPNP表现出明显更高的黄素封装效率.
- SPNP-Cur复合体显示出更好的热稳定性,紫外线保护,并大大提高了Cur的生物可访问性.
- 抗氧化剂活性受到pH值,溶剂,紫外线照射和消化的影响.
结论:
- 螺旋蛋白纳米粒子 (SPNP) 是黄素 (Cur) 的有效载体,提高了其稳定性和生物可访问性.
- 在营养药物供应方面,SPNP比原生螺旋蛋白 (SP) 提供更高的性能.
- 螺旋藻蛋白显示出作为功能性食品成分和营养保健品的理想,可持续的载体的承诺.
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