单细胞-淋巴细胞比率预测了2型糖尿病患者心血管疾病和死亡的情况
Han Li1,2,3,4, Yixuan Li1,2,3,4, Wenwen Guo1,2,3,4
1Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal of diabetes investigation
|November 6, 2024
概括
在2型糖尿病患者中,非常低和高的单细胞/淋巴细胞比率与心血管死亡风险增加有关,这表明U形关系.
科学领域:
- 心血管疾病流行病学
- 糖尿病研究研究 糖尿病研究
- 免疫学和炎症 免疫学和炎症
背景情况:
- 2型糖尿病中氧化应激增加可能会改变单细胞与淋巴细胞比率 (MLR) 和心血管疾病 (CVD) 死亡率之间的关联.
- 在2型糖尿病患者中,MLR的预后意义仍在调查中.
研究的目的:
- 调查单细胞与淋巴细胞比率在预测2型糖尿病患者死亡风险中的预后意义.
主要方法:
- 来自国家健康和营养检查调查 (1999-2010) 的2,954名2型糖尿病患者的分析.
- 死亡率数据 (所有原因和心血管) 从国家死亡指数获取到2019年12月31日.
- 使用考克斯回归,限制立方线和时间依赖的ROC曲线分析来评估预测作用.
主要成果:
- 在平均12.4年的随访期间,共有1007人死亡 (252人死于心血管疾病).
- 升高的MLR显示出剂量与反应的关系,增加了全因死亡风险.
- 在MLR和心血管死亡率之间观察到U形关系,低MLR和高MLR都与风险增加有关.
结论:
- 在2型糖尿病患者中,MLR和心血管死亡率之间存在U形关系.
- 非常低和非常高的MLR值都与该人群中心血管死亡风险增加有关.
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