在喘儿童中持续空气流限制预测和风险因素分析:回顾性队列研究
Shiqiu Xiong1,2, Chunyu Tian1, Mingjun Shao1
1Department of Allergy, Center for Asthma Prevention and Lung Function Laboratory, Children's Hospital Capital Institute of Pediatrics, Beijing, China.
Pediatric pulmonology
|November 6, 2024
概括
喘恶化和不良坚持预测儿童可逆持续气流限制 (RPAL). 高BMI和肺炎史预测不可逆转的PAL (IPAL),使早期风险识别成为可能.
科学领域:
- 儿科肺病学 儿科肺病学
- 喘研究 喘研究
- 临床风险预测预测
背景情况:
- 喘儿童持续的空气流量限制 (PAL) 与预后不佳有关.
- 确定PAL的风险因素对于早期干预至关重要.
研究的目的:
- 为了确定患有喘的儿童发展持续空气流限制 (PAL) 的风险因素.
- 开发和验证用于识别高风险喘儿童的预测模型.
主要方法:
- 在2年内对2072名患有喘的儿童 (5-16岁) 进行回顾性研究.
- 后勤回归分析以确定可逆PAL (RPAL) 和不可逆PAL (IPAL) 的风险因素.
- 开发和验证基于多变量逻辑回归的预测模型,使用名ogram可视化.
主要成果:
- 14.72%的患者发生了PAL.
- 喘恶化史和不良坚持是RPAL的危险因素.
- 高BMI (>19.0 kg/m2) 和肺炎史是IPAL的危险因素.
- 预测模型表现出良好的区分能力 (AUC从0.73到0.79不等).
结论:
- 喘恶化史和不良坚持是RPAL的关键预测因素.
- 增加的BMI和先前的肺炎增加了IPAL的风险.
- 开发的预测模型有效地识别了患PAL的高风险儿童.
相关概念视频
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Factors Affecting Pulmonary Ventilation
1.2K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.2K
Asthma: Pathogenesis and Management
359
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
359
Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K
Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K


