症状性多发性硬化症治疗对妊娠结果的影响
Laura Witt1,2, Sabrina Haben1, Karen Dost-Kovalsky1
1Department of Neurology, St. Josef-Hospital, Katholisches Klinikum Bochum, Ruhr-University Bochum, Bochum, Germany.
概括
多发性硬化症 (MS) 患者在生育年龄期间使用症状治疗 (ST) 是常见的. 怀孕期间的ST暴露并没有增加不良结果,这表明它对患MS的孕妇的安全性.
科学领域:
- 神经学 神经学
- 生殖医学 生殖医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在患有多发性硬化症 (MS) 的生育年龄妇女中,症状治疗 (ST) 的使用尚未得到充分证实.
- 关于怀孕期间ST暴露对怀孕结果的影响的数据有限.
研究的目的:
- 检查MS怀孕前,怀孕期间和产后的MS患者的ST使用模式.
- 为了评估与ST暴露有关的怀孕结果.
主要方法:
- 来自德国多发性硬化症和怀孕登记处的怀孕数据的分析.
- 对ST暴露 (n=282) 和ST无接触 (n=536) 怀孕之间的怀孕结果进行比较,并与疾病修饰疗法和年龄相匹配.
主要成果:
- 超过43%的怀孕在怀孕前和产后期间使用ST;11.5%的怀孕前和怀孕期间使用ST.
- 抗抑郁药,止痛药和抗药是最常用的ST类药物.
- 怀孕期间的ST暴露并没有提高不良妊娠结果,重大先天性异常或并发症的发生率.
结论:
- 几乎50%的MS患者从怀孕前到产后使用ST,约12%的妇女在怀孕前和怀孕期间使用ST.
- 在怀孕期间使用ST并没有对这一队列的怀孕结果产生负面影响.
- 需要进一步的研究来根据药物类别对ST效应进行分层,以改善MS患者的计划生育建议.
相关概念视频
Myasthenia Gravis: Overview and Treatment
1.2K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.2K
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K


