在阳性免疫化学便隐性血液检测患者的结肠镜后上部胃肠道恶性瘤:澳大利亚数据链接研究
Sahar Pakneshan1,2, Naomi Moy2, Ayesha Shah1,2,3
1Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Journal of gastroenterology and hepatology
|November 6, 2024
概括
阳性免疫化学便隐性血液测试 (iFOBT) 个体的上部胃肠道癌症的发病率更高. 这表明,将胃镜添加到结肠镜查中可能会改善这些癌症的早期检测.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 免疫化学便隐性血液测试 (iFOBT) 查可以识别个人进行结肠镜检查,但大多数人没有下部胃肠道病变.
- 关于iFOBT阳性患者上部胃肠道 (UGI) 癌症风险的数据有限.
研究的目的:
- 调查iFOBT阳性个体在结肠镜检查后三年内UGI恶性瘤的发生率.
- 将iFOBT阳性患者的UGI癌症率与普通人群进行比较.
主要方法:
- 对于接受结肠镜检查的50-75岁IFOBT阳性患者的回顾性分析.
- 通过昆士兰癌症登记处识别UGI癌症,并与人口数据进行比较.
主要成果:
- 0.23%的参与者在结肠镜检查后三年内被诊断出患有UGI癌症.
- 与普通人群相比,食道癌和胃癌的发病率显著增加 (分别是2.7倍和7.5倍).
- 75%的UGI癌症将呈现为无法解释的正面iFOBT结果.
结论:
- 阳性iFOBT结果的个人患胃癌和食道癌的风险要大得多.
- 将胃镜整合到iFOBT阳性患者的监测中,可能有利于检测UGI恶性瘤.
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