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乳腺癌和妇科癌症后的全身激素治疗:意大利专家组的共识意见
Angelo Cagnacci1, Paola Villa2, Giuseppina Paola Grassi3
1Teaching Unit of Obstetrics and Gynecology, DINOGMI San Martino Hospital of Genova, Genova, Italy.
Climacteric : the journal of the International Menopause Society
|November 6, 2024
概括
这一共识为妇科癌症后使用雌激素治疗 (ET) 或激素治疗 (HT) 提供了指导. 建议因癌症类型,受体状况和患者病史而异,强调对特定恶性瘤的谨慎.
科学领域:
- 妇科瘤学 妇科瘤学
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
背景情况:
- 在癌症后使用更年期激素治疗 (HT) 是一个复杂的临床决定.
- 以前的指南缺乏针对各种妇科和乳腺癌类型的具体建议.
研究的目的:
- 制定关于使用雌激素治疗 (ET) 或结合雌激素-孕激素激素治疗 (HT) 治疗乳腺癌和妇科癌症的共识意见.
- 为管理癌症幸存者的更年期症状的临床医生提供基于证据的建议.
主要方法:
- 意大利更年期研究小组制定了一份共识意见.
- 共识是基于癌症复发风险,类固醇受体状态,辅助疗法和癌症后ET/HT数据.
主要成果:
- 在癌,黑色瘤,宫癌 (注意腺癌) 和某些子宫内膜癌 (FIGO I-II阶段依赖雌激素,不包括黑人女性,可能不依赖雌激素) 之后,允许使用ET/HT.
- 在腺癌,大多数子宫瘤,粒状细胞瘤,低度血清性卵巢癌和血清性边缘性卵巢瘤之后,建议对ET/HT进行谨慎或禁忌.
- 在雌激素受体 (ER) /孕受体 (PR) 阳性乳腺癌后使用ET / HT需要非常小心,而在ER / PR阴性乳腺癌后可能是允许的.
结论:
- 该共识提供了针对妇科和乳腺癌后ET/HT使用的细微建议,根据特定的癌症类型和受体状态量身定制.
- 对个体患者的因素和癌症特征的仔细考虑在决定ET/HT时至关重要,以便在幸存者中管理更年期症状.
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