分离非热血小板作为库存短缺的应急措施
Herleen Rai1, Kyle Forsythe1,2, Nyle Smith1
1Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
Transfusion
|November 6, 2024
概括
用于输血的分离非血小板 (PLT) 是可行的,即使在24小时的存储后,也不会影响体外质量. 非病原体减少的PLT显示出更好的患者反应,这表明在短缺期间优先考虑.
科学领域:
- 输血医学 输血医学
- 血液学 血液学 血液学
- 血液银行 血液银行
背景情况:
- 分离非血小板 (PLT) 单位可以在短缺期间增加库存.
- 长期储存在气体透性分量袋中对PLT质量和输血结果的影响尚不清楚.
研究的目的:
- 为了在体外评估存储在阿利克袋中长达24小时的异位性血小板的质量.
- 评估接受分裂血小板单位的成年患者的输血反应.
主要方法:
- 在实验室中评估了PLT质量和血栓形成显微镜 (TEG) 在存储了8或24小时的PLT中.
- 在接受分PLT单位输血的成年人中,对PLT增量和校正计数增量 (CCI) 的回顾性分析.
主要成果:
- 储存期间没有观察到PLT计数,WBC计数或平均血小板体积的显著差异.
- 与基线相比,TEG R时间在24小时后显著增加.
- 与非病原体减少 (PR) 分割的PLT相比,与PR分割相比,非病原体减少 (PR) 分割的PLT显示出更高的中位数PLT计数增量和CCI.
结论:
- 将PLT存储在限额袋中长达24小时不会对体外质量产生不利影响.
- 分割APHERESIS PLT是一种可行的策略,可以在短缺期间管理库存.
- 优先考虑非PR PLT进行分割可能会导致患者输血反应的改善.
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