组织工程食道移植的临床翻译:患者已经为我们做好了准备吗?
N Durkin1,2, M Pellegrini1,2,3, V Karaluka2
1Stem Cell and Regenerative Medicine Section, Developmental Biology and Cancer Research and Teaching Department, Zayed Centre for Research Into Rare Disease in Children, UCL Great Ormond Street Institute of Child Health, London, UK.
Pediatric surgery international
|November 6, 2024
概括
患者和护理人员对长间隔食道缩 (OA) 组织工程的态度是积极的. 大多数参与者对组织工程 (TE) 持乐观态度,并希望参与未来的TE产品开发重点小组.
科学领域:
- 再生医学是一种再生医学.
- 生物技术是生物技术.
- 儿科手术 儿科手术
背景情况:
- 长间隔食道缩症 (OA) 带来了重大的重建挑战.
- 组织工程 (TE) 为食道置换提供了一个潜在的解决方案.
- 了解患者和护理人员的观点对于临床翻译至关重要.
研究的目的:
- 评估患者和护理人员对使用组织工程 (TE) 来治疗长间隙食道 (OA) 的态度.
- 为了衡量TE概念的接受度,包括细胞采购和生物材料.
- 为了告知TE治疗OA策略的发展.
主要方法:
- 进行了一次参与活动,与70名患者/家长参与了OA患者组TOFS.
- 在演示前和演示后,使用5分利克尔特尺度衡量了对TE的态度.
- 使用曼-惠特尼测试进行了统计分析.
主要成果:
- 43名与会者做出了回应,主要是家长/照顾者 (56%) 和患者 (21%).
- 大多数与会者 (85%) 之前对 TE 有意识; 15% 认为它是一个新概念.
- 呈现后对TE的感知显著改善 (中位数为4至5,p < 0.0001),细胞生长 (89%) 和动物产品 (61%) 的接受率高.
- 96%的人表示有兴趣参加关于TE产品开发的焦点小组.
结论:
- 利益相关者的意见对于TE结构的临床实施至关重要.
- 对 TE 构造的积极接待支持其进一步发展.
- 一个OA特定的焦点小组将指导TE疗法的翻译.
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