二次性胸膜功能障碍是慢性中风中异常的大规模神经动态的基础.
Phillip R Johnston1,2, John D Griffiths3,4,5,6, Leanne Rokos2,4
1Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada.
概括
脑卒中会导致广泛的神经减速,这是由于二次的胸膜退化,而不是直接的损伤. 这种胸膜功能障碍破坏了皮质胸膜电路,影响中风后的认知和语言功能.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 脑卒中经常导致广泛的神经减速和功能障碍.
- 在中风后,这些神经动态异常的确切原因仍然在很大程度上是未知的.
- thalamus 的二次退化越来越多地被认为是中风的后果.
研究的目的:
- 为了调查中风后神经减速的原因.
- 探索质体和皮质质体电路在中风后神经动态中的作用.
- 确定二次性乳头退化和功能结果之间的关系.
主要方法:
- 在慢性中风患者的磁脑电图 (MEG) 功率光谱上应用了神经生理学皮质大脑电路模型.
- 在患者和对照组之间比较模型估计的生理参数.
- 分析了光谱减速,次要的胸膜退化 (体积,微观结构,血流) 和认知/语言结果之间的相关性.
主要成果:
- 脑卒中患者在受损半球中表现出明显较低的内内抑制.
- 频谱减速与ipsilesional thalamus的整体次要变性强烈相关.
- 甲状腺退化,由甲状腺消抑制介导,与异常的大脑动态和较差的认知/语言结果有关,独立于病变体积.
结论:
- 脑卒中后的神经减速反映了由于二次的胸膜功能障碍引起的皮质体体内电路动力学中断.
- 胸膜消抑制在将二次胸膜退化与神经活动异常联系起来方面发挥着至关重要的作用.
- 泰拉马斯是理解和潜在治疗中风后脑功能障碍和相关残疾的关键目标.
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