USP30-AS1通过NF-κB/MYBBP1A信号抑制结肠癌细胞的炎症反应
Ruonan Wang1, Xiaolin Li1, Yapei Jiang1
1State Key Laboratory of Chemical Oncogenomics, Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Inflammation
|November 6, 2024
概括
长非编码RNAUSP30-AS1在结直肠癌中被下调,通过抑制MYBBP1A/NF-κB炎症途径来抑制瘤生长. 这将USP30-AS1确定为结直肠癌的潜在治疗点.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 长非编码RNAs (lncRNAs) 的异常表达与CRC的发展和进展有关.
- 在CRC中lncRNA USP30-AS1的特定作用仍然在很大程度上未被探索.
研究的目的:
- 研究lncRNAUSP30-AS1在结直肠癌中的作用.
- 阐明USP30-AS1在CRC进展中的潜在分子机制.
- 评估USP30-AS1作为CRC的潜在治疗点.
主要方法:
- 对结直肠癌组织中USP30-AS1表达的分析以及与患者存活率的相关性.
- 丰富分析以确定与USP30-AS1.1.相关的途径.
- 试验室功能测定包括基因淘汰和过度表达.
- 研究USP30-AS1,MYBBP1A和NF-κB信号通路之间的相互作用.
主要成果:
- 在CRC组织中,USP30-AS1显著下调,与患者存活率较差相关.
- USP30-AS1的表达通过促炎性刺激 (LPS,TNF-α) 进行上调.
- 击败USP30-AS1增强了NF-κB活性和炎症基因表达 (NLRP3,IL-1β,IL-18).
- USP30-AS1与MYBBP1A相互作用,以抑制NF-κB信号传递.
结论:
- 在结直肠癌中,USP30-AS1作为瘤抑制剂起作用.
- USP30-AS1通过负面调节MYBBP1A/NF-κB信号通路来抑制CRC细胞的生长.
- USP30-AS1代表着对结直肠癌治疗的有前途的新型治疗标.
更多相关视频
相关概念视频
NF-κB-dependent Signaling Pathway
7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.2K
Co-activators and Co-repressors
7.3K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
7.3K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Interactions Between Signaling Pathways
6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Drugs for Treatment of Ulcerative Colitis in IBD
124
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
124


