在青少年大麻使用开始之前和之后的精神病频谱症状
K Juston Osborne1, Deanna M Barch1,2,3, Joshua J Jackson2
1Department of Psychiatry, Washington University in St Louis, St Louis, Missouri.
JAMA psychiatry
|November 6, 2024
概括
青少年大麻使用可能通过共同的脆弱性或自我治疗与精神病有关,在使用之前症状会增加. 这些发现强调了在大麻精神病研究中需要考虑这些因素的必要性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 青少年使用大麻与精神病风险有关.
- 其他解释包括共享的脆弱性或对痛苦的自我治疗.
- 了解这些关系对于青少年心理健康至关重要.
研究的目的:
- 调查青少年大麻使用和精神病谱症状之间的因果关系.
- 测试共享脆弱性,自我治疗和直接风险的假设.
- 模拟大麻开始之前和之后的精神病症状轨迹.
主要方法:
- 使用青少年大脑认知发展 (ABCD) 研究数据的纵向队列研究.
- 包括11,868名9-10岁的青少年在基线,随访4年.
- 不连续增长曲线建模分析了与大麻启动相对的精神病症状轨迹.
主要成果:
- 使用大麻的青少年报告了更多的精神病症状和痛苦,支持共享的脆弱性.
- 精神病症状和痛苦增加,导致大麻开始,支持自我治疗.
- 在大麻开始后,精神病症状增加的证据是混合的.
结论:
- 共享的脆弱性和自我治疗是大麻与精神病相关的重要因素.
- 这些发现强调了需要将这些替代模型纳入研究的必要性.
- 结果对理解和干预青少年心理健康和物质使用有意义.
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