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在脊髓损伤的人群中,增强了三腕的抑制输入

Carley L P Butler^1,2,3,4, Sina Sangari¹, Bing Chen^1,4

¹Shirley Ryan AbilityLab, Chicago, IL, USA.

The Journal of physiology

|November 6, 2024

概括

椎脊髓损伤 (SCI) 患者在肘部伸缩器表现出比曲器更大的弱点. 这项研究揭示了SCI后肘部伸展器中皮层抑制的增加,导致功能缺陷.

科学领域:

神经科学是一个神经科学.
发动机控制器的控制器
脊髓损伤研究脊髓损伤研究

背景情况:

椎脊髓损伤 (SCI) 经常导致肘部伸展肌肉比肘部 flexors 更显著的软弱.
在SCI后这种差异性功能缺陷背后的精确神经机制尚不清楚.

研究的目的:

调查神经机制,特别是皮层内抑制,导致长期宫SCI后肘伸展肌肉疲弱.
在SCI和没有SCI的个体中,比较肘部曲肌和伸展肌之间的皮层内抑制水平.

主要方法:

在初级运动皮层上利用低强度的横磁刺激 (TMS) 来测量自愿电肌图学活动 (svEMG) 的抑制.
在慢性宫SCI和健康对照人群中,在亚最大同位数收缩 (10% MVC) 期间评估两肌 (柔肌) 和三肌 (延伸肌) 的svEMG.
分析了svEMG延迟,持续时间和区域作为皮质内抑制的指标.

主要成果:

与对照人群相比,SCI参与者的三脚 (延伸器) 中发现了长时间的svEMG延迟和持续时间.
观察到三肌的svEMG区域在两组两肌相比显著更大,SCI参与者的进一步增加,表明肘部伸展期间有更大的抑制.
证明 svEMG 面积和最大自发收缩 (MVC) 强度之间存在负相关性,这表明减少抑制与更大的运动输出有关.

结论:

这些发现支持对控制肘部伸展器的皮质脊髓管道存在大量的皮质内抑制输入,在慢性宫SCI后更为明显.
肘延伸器中这种增强的抑制可能是一个关键的神经机制,有助于在宫SCI后观察到的特征性功能缺陷.

关键词:

皮质脊椎管道的皮质脊椎管道肘部延伸/曲肘部延伸/曲肘部延伸/曲肘部延伸/曲这是一种抑制性内部神经元.皮层内抑制的抑制.神经生理学神经生理学脊髓损伤导致的脊髓损伤

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