在长期幸存者中,非艾滋病毒并发症负担更高
Thom W Vonder1, Tania Mudrikova
1Department of Internal Medicine & Infectious Diseases, University Medical Center Utrecht, Utrecht, The Netherlands.
AIDS (London, England)
|November 6, 2024
概括
长期的艾滋病毒幸存者 (LTS) 经历了比现代ART时代诊断的个人更大的并发症负担,即使在同一个年龄. 这凸显了早期艾滋病毒治疗对长期健康结果的持久影响.
科学领域:
- 传染性疾病 传染性疾病
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 随着抗逆转录病毒疗法 (ART) 的进步,艾滋病毒感染已经发展成为一种可管理的慢性疾病.
- 长期艾滋病毒幸存者 (LTS) 可能面临独特的健康挑战,由于感染和早期治疗方案的累积影响.
- 了解艾滋病毒感染老年人群的并发症负担对于全面的医疗保健至关重要.
研究的目的:
- 为了比较长期感染艾滋病毒的个人和在现代ART时代被诊断出来的人之间的并发症负担.
- 调查不同年龄相匹配的个体之间的健康状况差异,艾滋病毒诊断的持续时间不同.
主要方法:
- 追溯队列分析比较LTS (1996年之前诊断) 与现代ART时代 (mART) 组 (2006年后诊断).
- 使用年龄和性别匹配进行队列比较.
- 评估了九个并发症领域:心血管,肌肉骨,神经,瘤,肝脏,肺,脏,精神病/认知和代谢.
主要成果:
- 分析了88名LTS和88名mART个体 (平均年龄60岁).
- 在LTS中,共患病域的平均数量显著高 (2.6对1.9;P=.001).
- 代谢和心血管疾病在两组中最为普遍;LTS并发症分布类似于10岁以上的mART亚组.
结论:
- 与最近的诊断相比,长期存在的艾滋病毒感染与更大的并发症负担有关,即使在具有相似时间年龄的个人中也是如此.
- 总ART持续时间和年龄是艾滋病毒感染者的并发症负担的重要预测因素.
- 这些发现强调了长期监测和管理艾滋病毒感染者的健康的重要性,特别是LTS.
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