Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jun 8, 2025

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.0K

ADTGP:使用高斯过程回归纠正单细胞抗体测序数据.

Alex C H Liu1,2, Steven M Chan1,2

  • 1Princess Margaret Cancer Centre, Toronto, Ontario, M5G 1L7, Canada.

Bioinformatics (Oxford, England)
|November 6, 2024
PubMed
概括
此摘要是机器生成的。

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Extracellular vesicles from aged individuals trigger mitochondrial dysfunction in haematopoietic progenitor cells.

Haematologica·2026
Same author

Aberrant oxidative metabolism selects for <i>TET2</i> -deficient hematopoietic stem and progenitor cells.

bioRxiv : the preprint server for biology·2026
Same author

Blood-based epigenetic instability linked to human aging and disease.

Nature communications·2026
Same author

Single-cell proteogenomic analysis of clonal evolution in PDX models of AML treated with IDH inhibitors.

Blood neoplasia·2026
Same author

Real-world experience with CPX-351 for secondary acute myeloid leukaemia: Comparison with FLAG-IDA in a propensity score matching analysis.

British journal of haematology·2025
Same author

Novel and emerging therapeutic strategies for clonal hematopoiesis.

Haematologica·2025

我们开发了ADTGP,这是用于单细胞蛋白序列数据分析的R包. 它使用高斯过程回归纠正技术噪声,提高研究人员的数据解释性.

科学领域:

  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.
  • 单细胞分析 单细胞分析

背景情况:

  • 单细胞蛋白质测序产生复杂的数据与技术噪音.
  • 解释蛋白质表达需要准确的噪声校正.

研究的目的:

  • 引入ADTGP,这是一个R包,用于纠正单细胞蛋白质测序数据中的滴点特定技术噪声.
  • 提高单细胞蛋白质数据的解释性.

主要方法:

  • 使用高斯过程回归来建模和纠正技术噪声.
  • 模型蛋白质表达分布以同型对照计数为条件.
  • 需要原始蛋白质计数,同型控制计数和设计矩阵.

主要成果:

  • ADTGP有效地纠正滴滴特定的技术噪声.
  • 通过噪声校正,可以实现更好的数据解释性.
  • 该包为分析单细胞蛋白质数据提供了一种强大的方法.

结论:

  • ADTGP是一个有价值的R包,用于单细胞蛋白序列数据分析.
  • 它提供了一种统计学上合理的噪声校正方法.

更多相关视频

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

12.3K
Detection of Copy Number Alterations Using Single Cell Sequencing
09:45

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

11.6K

相关实验视频

Last Updated: Jun 8, 2025

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.0K
Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

12.3K
Detection of Copy Number Alterations Using Single Cell Sequencing
09:45

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

11.6K
  • 该包对研究人员来说是可访问和用户友好的.