肠道微生物群疾病和代谢综合征:一个交叉流程的故事
Penghui Nie1, Liehai Hu1, Xiaoyan Feng1
1State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Nutrition reviews
|November 6, 2024
概括
肠道微生物群 (GM) 通过相互交叉交互显著影响代谢综合征 (MetS). 本综述详细介绍了MetS中的转基因变化以及短链脂肪酸 (SCFA) 在其病原和治疗中的作用.
科学领域:
- 微生物学 微生物学
- 代谢疾病 代谢疾病
- 人类微生物组 人类微生物组
背景情况:
- 人的肠道微生物群 (GM) 在维持胃肠道,免疫和代谢平衡方面发挥着至关重要的作用.
- 人们越来越认识到肠道微生物群对代谢综合征 (MetS) 的发展有着显著的影响.
- 肠道微生物群和代谢综合征之间存在着复杂的,相互交叉的交叉.
研究的目的:
- 系统地审查肠道微生物群如何通过宿主-微生物代谢轴诱导代谢综合征.
- 详细说明与代谢综合征相关的肠道微生物群组成的具体变化.
- 突出短链脂肪酸 (SCFA) 在代谢综合征和相关疾病中的作用.
主要方法:
- 对有关肠道微生物群和代谢综合征的现有文献进行系统审查.
- 分析了详细介绍宿主-微生物代谢轴在MetS病变发生过程中的研究.
- 关于短链脂肪酸及其对MetS的影响的研究综述.
主要成果:
- 肠道微生物群通过宿主-微生物代谢轴直接和间接地为MetS发展做出贡献.
- 肠道微生物群组成的特定变化是MetS的特征.
- 短链脂肪酸 (SCFA) 是关键的微生物代谢物,对MetS及其相关条件有显著影响.
结论:
- 了解肠道微生物群在MetS中的作用对于开发有针对性的治疗策略至关重要.
- 短链脂肪酸在MetS.中的治疗干预方面是一个有前途的领域.
- 对肠道微生物群-MetS轴的进一步研究可以导致新的治疗方法.
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