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通过计算机模拟,提高质体对两性共聚物的封装性能

Bo-Han Chen1, Qiang-Sheng Xia1, Juan Li2

  • 1School of Electronic Engineering and Intelligent Manufacturing, Anqing Normal University, Anqing 246133, China.

The journal of physical chemistry. B
|November 6, 2024
PubMed
概括

研究人员通过消散粒子动力学模拟优化了两性共聚物的脂质体封装. 定制交互增强了药物加载能力,并揭示了药物输送应用的七种不同的聚合结构.

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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