皮质体膜回路的功能性质,这些回路针对的是副腹腔体膜神经元
Guillermo Aquino-Miranda1, Dounya Jalloul2, Xu O Zhang2
1Department of Neurobiology and Anatomy, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA.
Neuron
|November 6, 2024
概括
从前膜皮层 (PL) 到前腹腔前核 (aPVT) 的高频大脑信号可以限制神经元的发射率,影响有动机的行为. 来自体网状核 (TRN) 的抑制信号调节这些效应.
科学领域:
- 神经科学是一个神经科学.
- 神经生物学 神经生物学 神经生物学
- 系统神经科学 系统神经科学
背景情况:
- 皮层甲状腺突出通常表现出适度的发射速度,调节甲状腺中继神经元.
- 高阶皮质体内路径在调节体内核活动中的作用仍然不太清楚.
研究的目的:
- 为了研究前临界皮层 (PL) 投射到前侧腹腔垂体核 (aPVT) 的发火特性.
- 确定PL-aPVT通路活动如何影响aPVT神经元的发射,并调节有动机的行为.
主要方法:
- 在老鼠中进行电生理学记录以评估神经元活动.
- 高频刺激的PL-aPVT投影.
- 在aPVT神经元中分析动作潜能幅度和发射速率.
- 调查来自前中体网状核 (avTRN) 的抑制输入.
主要成果:
- PL-aPVT投影表现出高频活性,与其他皮质体内路径不同.
- 高频刺激在很大一部分aPVT神经元中诱导了脱极化阻断 (DB),限制了发射速度.
- 前中体网状核 (avTRN) 根据尖峰忠实度和DB存在差异调节aPVT发射.
结论:
- 高频PL-aPVT输入可以通过脱极化阻断调节aPVT神经元的刺激性,以频率依赖的方式影响动机行为.
- avTRN输入在调节PL输入对aPVT活动的影响方面发挥着至关重要的作用,从而控制动机行为.
相关概念视频
Diencephalon: Thalamus and Information Relay
1.5K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.5K
Neural Circuits
1.1K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.1K
Diencephalon: Anatomical Regions
1.7K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses...
1.7K
Diencephalon: Hypothalamus and Coordination
1.4K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
1.4K
Direct Motor Pathways
1.8K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
1.8K
Major Somatic Sensory Pathways
908
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
908


