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创伤患者的血高流动性组盒-1和加列-9及其预后潜力

Toshiro Niki¹, Haorile Chagan-Yasutan^2,3, Daisuke Furushima^4,5

¹Department of Immunology, Faculty of Medicine, Kagawa University.

The Tohoku journal of experimental medicine

|November 6, 2024

概括

高流动性组盒-1 (HMGB-1) 在创伤患者中显示出预后潜力,与加勒-9 (Gal-9) 不同. HMGB-1可以作为一个有价值的血液生物标志物来预测创伤结果.

科学领域:

生物化学生化学
免疫学免疫学免疫学
创伤研究创伤研究

背景情况:

损伤相关分子模式 (DAMPs) 是由受损组织释放的内源分子.
在创伤伤害后,DAMP与炎症反应和受损的免疫平衡有关.

研究的目的:

在创伤患者中检查血中加勒-9 (Gal-9) 和高流动性组盒-1 (HMGB-1) 的水平.
评估这些DAMP在区分幸存者和已故患者的预后潜力.

主要方法:

在创伤患者的入院和7天内测量血Gal-9和HMGB-1水平.
DAMP度与预后参数之间的相关性分析.
接收器操作特征 (ROC) 曲线分析用于预后歧视.

主要成果:

入院时Gal-9水平较高,并在48小时内正常化.
HMGB-1水平在入院时达到峰值,在7天内保持升高,与6个预后参数相关.
与Gal-9不同的是,HMGB-1可以区分幸存者和死亡患者,通过ROC分析显示了中度的预后潜力.

结论:

HMGB-1在创伤中的血液生物标志物中显示出显著的预后潜力.
HMGB-1对于预测创伤结果可能是有价值的,可能与其他生物标志物结合.

关键词:

与损伤相关的分子模式盖莱克-9-9的使用方法高流动性群体盒子-1 高流动性群体盒子-1 预后预后预后一个创伤的创伤创伤.

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