转移性细胞癌的第一线和第二线治疗方法
Regina Barragan-Carrillo1, Eddy Saad2, Renee-Maria Saliby2
1Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
European urology
|November 6, 2024
概括
选择转移性细胞癌 (mRCC) 的治疗方法需要平衡疗效和毒性. 本指南有助于临床医生选择一线和二线疗法,以改善mRCC患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
背景情况:
- 转移性细胞癌 (mRCC) 的治疗环境迅速发展,改善了患者的治疗结果.
- 当前的治疗策略提供了更多的选择,但需要仔细选择.
研究的目的:
- 为临床医生提供一本关于选择一线和二线mRCC治疗的实用指南.
- 综合当前的证据,以优化mRCC管理.
主要方法:
- 我们对PubMed和Embase进行了全面的文献搜索.
- 包括手动搜索指南和会议记录.
- 进行了作者共识的叙事审查.
主要成果:
- 第一线选择包括基于免疫检查点抑制剂 (ICI) 的组合或氨酸激酶抑制剂 (TKI).
- 治疗决策取决于IMDC风险,患者状态,安全性和疾病特征.
- 第二线治疗需求尚未得到满足;TKIs和HIF2a抑制剂显示出有前途. 不建议重新挑战ICI.
结论:
- 最佳的mRCC治疗选择需要平衡疗效,毒性和患者偏好.
- 在第一线和第二线治疗之间过渡时,个性化护理至关重要.
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