末期和慢性病在经典的膀外缩:一个回顾性的 muti-机构队列研究
Joshua D Roth1, Diana Bowen2, Molly E Fuchs3
1Riley Children's Health at Indiana University Health, USA.
Journal of pediatric urology
|November 6, 2024
概括
患有经典膀外缩 (CBE) 的患者面临患末期病 (ESKD) 和慢性病 (CKD) 的显著风险. 长期监测对于这一群体至关重要,因为与普通人群相比,风险较高.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
背景情况:
- 典型的膀外缩 (CBE) 通常在出生时表现为正常的功能,但成年后可能出现功能恶化.
- 在CBE患者中,末期病 (ESKD) 和慢性病 (CKD) 的发生率尚未得到充分确立.
- 以前的研究集中在手术结果上,强调需要了解长期脏健康.
研究的目的:
- 为了确定ESKD的发病率和CKD第3阶段或更高阶段 (CKD3+) 的患病率在CBE患者的多机构队列中.
- 将CBE患者的病风险与普通人群进行比较.
- 为了确定可能导致衰退的潜在因素,在这个队列.
主要方法:
- 五个三级护理中心的医疗记录的回顾性审查.
- 定义的ESKD是永久性透析或移植;定义的CKD3+是估计的膜过率 (eGFR) <60毫升/分钟/1.73米2.
- 利用生存分析和费舍尔精确测试来分析功能结果并比较风险.
主要成果:
- 三名患者 (1.5%) 在平均年龄为23.4岁时发展出ESKD.
- 累积ESKD风险在20岁时为1%,在30岁时为5%,明显高于一般人群.
- 在青少年中,CKD3+的患病率为4%,在成年人中为8%,根据手术方法或中心没有显著差异.
结论:
- 与普通人群相比,患有CBE的患者患ESKD和CKD的风险高且不小.
- 需要进一步研究可改变的因素,例如膀出口阻力.
- 长期,可靠的随访对于监测CBE患者的脏健康至关重要.
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