GHRH和前列腺的作用
Laura Muñoz-Moreno1, Irene D Román1, Ana M Bajo2
1Departamento de Biología de Sistemas. Unidad de Bioquímica y Biología Molecular (Research group "Cánceres de origen epitelial"), Universidad de Alcalá, Campus Científico-Tecnológico, 28871, Alcalá de Henares, Madrid, Spain.
Reviews in endocrine & metabolic disorders
|November 6, 2024
概括
增长激素释放激素 (GHRH) 和它的受体在前列腺癌中被发现. 新的GHRH受体变体和强大的对抗剂在治疗前列腺疾病方面表现有前途.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 脑下垂体激素,包括生长激素释放激素 (GHRH),在20世纪60年代末至70年代初被分离出来.
- GHRH及其受体 (GHRH-R) 在正常组织,瘤和各种人类癌症中表达,包括前列腺癌 (PCa).
- GHRH-R的拼接变体 (SV) 在 pituitary 和 extrapituitary 组织中发现,包括瘤.
研究的目的:
- 调查前列腺组织中GHRH-R及其拼接变体的存在和作用.
- 探索GHRH-R对抗剂在前列腺相关疾病中的治疗潜力.
主要方法:
- 在正常的前列腺和PCa样本中检测和描述GHRH-R及其拼接变体 (SV1-SV4,新型SV).
- 对由GHRH激活的信号通路的分析 (AC/cAMP/PKA,Ras/Raf/ERK,PI3K/Akt/mTOR,JAK2/STAT3) 进行了分析.
- 评估GHRH-R抗体,特别是AVR系列的抗癌和抗炎活性在体外和体内.
主要成果:
- 在人类前列腺和PCa中检测到截断的GHRH-R拼接变体 (SV1-SV4) 和一种新型的SV.
- GHRH信号通路参与细胞存活,增殖和细胞因子分泌.
- 在GHRH-R抗体的AVR系列中,GHRH-R抗体显示出优异的抗癌和抗炎作用.
结论:
- 在前列腺癌中存在GHRH-R及其拼接变体,这表明它在疾病进展中起着作用.
- GHRH-R抗体,特别是AVR系列,是前列腺癌和其他相关疾病的有前途的治疗策略.
相关概念视频
Small GTPases - Ras and Rho
3.9K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
Three regulatory proteins control their activity:
3.9K
Disorders of the Male Reproductive System
338
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
338
The Ras Gene
6.2K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
Ras is a...
6.2K
Activation and Inactivation of G Proteins
6.8K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
6.8K
Testosterone: Functions and Regulation
560
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
560
GTPases and their Regulation
8.3K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒ small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
Large G-proteins,...
8.3K


