肠道病毒抗体:朋友和敌人
Chaldam Jespère Mbani1,2, Corentin Morvan1, Magloire Pandoua Nekoua1
1Laboratoire de Virologie URL3610, Univ. Lille et CHU Lille, Lille, France.
Reviews in medical virology
|November 6, 2024
概括
针对肠道病毒 (EV) 的抗体可以中和或增强感染. 对EV感染的抗体依赖增强 (ADE) 需要考虑开发有效的疫苗和疗法.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 肠道病毒 (EV) 通过细胞受体结合启动复制,将基因组释放到宿主细胞质中.
- 中和抗体 (NAbs) 可以通过各种机制抑制EV感染.
- 感染的抗体依赖增强 (ADE) 可能发生,导致更严重的病理.
研究的目的:
- 审查抗体介导肠道病毒中和和增强的机制.
- 讨论抗体在诊断EV感染中的作用及其与慢性疾病的联系.
- 突出开发抗EV抗体和疫苗的考虑因素,特别是在ADE方面.
主要方法:
- 关于肠道病毒与抗体相互作用研究的文献综述.
- 在体外和体内对病毒中和ADE的数据的分析.
- 检查FcγRs在EV感染增强中的作用.
主要成果:
- 与EV结合的抗体可以中和感染,或者在某些情况下增强感染 (ADE).
- EV感染的ADE是由FcγRs介导的免疫细胞,如单细胞和巨细胞.
- 抗体对于诊断EV感染至关重要,并具有潜在的治疗和预防应用.
结论:
- 了解中和和ADE对于开发安全有效的EV疫苗和基于抗体的疗法至关重要.
- 在制定预防严重肠道病毒疾病的干预措施时,必须仔细考虑ADE.
- 抗体仍然是EV诊断,监测和潜在治疗策略的重要工具.
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