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Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...

Genetic Material

Genetic Material

Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.

Genome Size and the Evolution of New Genes

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.

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Updated: Jun 8, 2025

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

Published on: October 5, 2018

使用数据引用探索器识别基因组数据的使用情况.

Neil Byers¹, Charles Parker¹, Chris Beecroft¹

¹DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California, 94720, USA.

Scientific data

|November 6, 2024

概括

此摘要是机器生成的。

数据引用探索器 (DCE) 通过使用尚未正式引用的基因组数据自动查找科学文献. 这种工具可以提高数据引用的准确性,并有助于跟踪基因组数据资源的影响.

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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

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Last Updated: Jun 8, 2025

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

Published on: October 5, 2018

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

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科学领域:

基因组学就是基因组学.
生物信息学是一种生物信息学.
科学文献分析科学文献分析

背景情况:

数据和出版物测序的指数增长需要自动化方法来将文献与基因组信息联系起来.
由于数据量,科学文献和基因组数据之间的关联的手动策划变得越来越不可行.

研究的目的:

引入数据引用探索器 (DCE),这是一个自动化服务,旨在识别利用基因组数据而没有正式引用的科学出版物.
加强基因组数据资源及其相关文献的管理和可发现性.

主要方法:

数据引用探索器 (DCE) 服务的开发.
利用自动化方法发现和将科学文献与相关的基因组数据集联系起来.
将自动发现与手动策划进行比较,以确定数据与文献的关联.

主要成果:

DCE成功地识别了包含未正式引用的基因组数据的科学文献,扩大了JGI数据产品的已知用例.
该服务提供一致的资源覆盖,元数据丰富,并识别冲突的元数据,超越手动策划限制.
实施DCE降低了劳动力成本,并提高了美国能源部联合基因组研究所 (JGI) 的基因组元数据的质量.

结论:

像DCE这样的自动化工具对于管理现代基因组数据和科学文献的复杂性至关重要.
该DCE增强了对JGI研究影响的理解,改善了数据生成的归因,并通过展示数据重复使用来鼓励数据共享.
该服务有助于更好地跟踪基因组数据的影响,并促进科学可复制性和数据可访问性.