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Updated: Jun 8, 2025

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
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通过AMFR介导的Flavivirus NS2A无化颠覆ER-phagy以增加病毒病原性

Linliang Zhang1, Hongyun Wang2, Chao Han2

  • 1School of Life Sciences, Hubei University, Wuhan, 430062, China.

Nature communications
|November 6, 2024
PubMed
概括

寨卡病毒 (ZIKV) 感染通过病毒NS2A蛋白降低了ER-phagy受体FAM134B,阻碍了ER循环,促进了长时间的感染. 缺少这种机制的突变ZIKV显示了减少的致病性.

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