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乳腺癌和肺癌之间的关联:双向的门德尔随机化研究

Xiaoqian Li¹, Junjie Liu¹, Jingyi Zhang¹

¹Department of Breast Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, 710061, China.

Scientific reports

|November 6, 2024

概括

乳腺癌 (BC) 幸存者患肺腺癌 (LUAD) 的风险增加,作为第二种主要癌症. 在BC幸存者中早期查和干预LUAD对于降低死亡率至关重要.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
流行病学流行病学

背景情况:

寿命的延长导致乳腺癌 (BC) 幸存者的第二次原发性癌症 (SPC) 发病率更高.
肺癌 (LC) 是BC幸存者中常见的SPC,影响生存率.
了解BC和LC之间的因果关系对于幸存者护理至关重要.

研究的目的:

使用孟德尔随机化研究乳腺癌和肺癌之间的潜在因果关系.
确定乳腺癌是否会增加患肺腺癌 (LUAD) 的风险,作为第二种原发性癌症.
探索反向因果关系:LUAD是否影响患乳腺癌的风险.

主要方法:

进行了一种双向的双样本孟德尔随机化 (MR) 分析.
来自乳腺癌协会联盟 (BCAC) 和肺癌跨学科研究 (TRICL) 的全基因组关联研究 (GWAS) 数据被利用.
使用逆方差加权 (IVW) 和MR-PRESSO方法来评估因果关系.

主要成果:

乳腺癌 (BC) 对患肺腺癌 (LUAD) 风险的显著因果影响被确定 (IVW:OR=1.060,P=0.024).
结果表明,患有BC的患者患上LUAD作为第二种原发性癌症的风险更高.
没有发现强有力的证据表明LUAD对发展BC的风险有因果作用.

结论:

乳腺癌与第二次原发性肺腺癌的风险增加有关.
经过BC的幸存者应该接受第二次原发性肺癌的强化查.
在BC幸存者中早期发现和治疗LUAD可能会降低死亡率.

关键词:

乳腺癌是什么? 乳腺癌是什么?因果关系影响因果关系影响.肺癌是一种肺癌.门德尔的随机化

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