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在COVID 19大流行期间的怀孕与与大流行前相比,与不同的肠道微生物组合有关

Therese A Rajasekera^1,2, Jeffrey D Galley^1,2, Lauren Mashburn-Warren³

¹Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Scientific reports

|November 6, 2024

概括

COVID-19 流行病改变了孕妇的肠道微生物组,显示出明显的细菌变化. 这些变化独立于怀孕期间报告的压力或抑郁症状.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

由于COVID-19大流行,造成了严重的心理社会压力,影响了日常生活.
怀孕伴随着对压力,焦虑和情绪障碍的高度脆弱性,这可能会改变肠道微生物群.
了解流行病对孕妇细菌组的影响至关重要.

研究的目的:

为了调查COVID-19大流行对孕妇肠道微生物组合的影响.
检查心理测量反应及其与大流行期间微生物组变化的相关性.

主要方法:

从2019年2月到2021年8月的前性队列研究 (N=12-26).
从怀孕个体收集心理测量数据和直肠微生物组扫描.
全长16SrRNA测序用于分析便微生物组的多样性和组成.

主要成果:

在大流行期间,在孕妇中观察到细菌多样性和组成的明显变化.
在流行病组中,病原性和鲜为人知的种群的相对丰度较低.
与大流行前相比,压力/抑郁症状没有显著差异,压力-症状相关性消散.

结论:

随着COVID-19的流行,孕妇的肠道微生物组发生了重大变化.
这些微生物组变化发生的独立于感知到的压力水平.
研究结果强调了大流行对母亲肠道微生物组的独立影响.

关键词:

在COVID-19大流行中,我们的肠道微生物组.怀孕怀孕怀孕怀孕压力压力压力压力

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