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Updated: Jun 8, 2025

Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay
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在USP12/46 deubiquitinases保护整体从ESCRT介导的溶酶体降解

Kaikai Yu1, Guan M Wang1, Shiny Shengzhen Guo1

  • 1Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany.

EMBO reports
|November 6, 2024
PubMed
概括

一个含有USP12/46,WDR48和WDR20的二基化复合物通过防止其溶酶体降解来稳定β-1整合素 (Itgb1). 这种复合物从内部化的Itgb1中去除了ubiquitin,促进了它的表面保留.

关键词:
在这里,dub,dub,dub是什么意思.这是ESCRT的特色.整体的整体是整体的USP12/USP46 在线阅读在Ubiquitination中使用.

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