空气污染物的联合协会对心脏代谢多病症的联合协会
Liang Xia1, Shan Zhou2, Liyuan Han1,3
1Department of Gynecology, Ningbo No.2 Hospital, Ningbo, 315010, Zhejiang, China.
对空气污染的高暴露增加了患心脏代谢多病症 (CM) 和全因死亡的风险,特别是在具有遗传倾向的个体中.
科学领域:
- 环境健康 环境健康
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 心脏代谢多病症 (CM) 是一个重大的公共卫生挑战.
- 空气污染是越来越多地被认为是各种疾病的环境风险因素.
- 了解空气污染和遗传易感性的综合影响对于风险分层至关重要.
研究的目的:
- 调查空气污染物联合暴露与心脏代谢多病症 (CM) 之间的关联.
- 检查空气污染与全因死亡率之间的关系.
- 探索空气污染和遗传风险评分 (GRS) 对CM和死亡率的综合影响.
主要方法:
- 根据对五种主要空气污染物的联合暴露计算了空气污染得分.
- 定义CM为至少有两个心脏代谢疾病的存在.
- 利用多状态回归模型分析疾病进展和死亡率.
- 纳入心血管疾病 (CVD) 和冠心病 (CHD) 的遗传风险评分 (GRS).
主要成果:
- 较高的空气污染评分与增加CM易感性和全因死亡率有显著的关联.
- 对于心血管疾病/心血管疾病的高GRS和高空气污染分数的个体,对发生的CM和全因死亡率的敏感性更大.
- 多州模型表明,空气污染得分升高有助于从无疾病状态到单一心脏代谢疾病,然后到CM,最终导致死亡的进展.
- 在联合空气污染物暴露和CM发展和全因死亡率之间观察到剂量依赖的关系.
结论:
- 对常见空气污染物的联合暴露显著增加了患心脏代谢多病症和所有原因死亡的风险.
- 遗传倾向,特别是心血管疾病和心血管疾病,加剧了空气污染对心脏代谢健康和生存的不良影响.
- 空气污染是心脏代谢疾病和死亡率进展的关键驱动因素,突显了环境干预的必要性.
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