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Updated: Jun 8, 2025

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对NPPS的依赖在RAS突变癌症中产生了可向的脆弱性

Rui-Xue Xia1,2, Pei-Chen Zou2, Jun-Ting Xie2

  • 1Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.

Acta pharmacologica Sinica
|November 6, 2024
PubMed
概括

研究人员确定核酸铁酸酶 (NPPS) 是RAS突变癌症的一个关键漏洞. 抑制NPPS或与hxokinase 1 (HK1) 的相互作用有效地抑制了瘤生长,为这些具有挑战性的癌症提供了新的治疗策略.

关键词:
一个HK1一个HK1这是NPPS的NPPS.发生RAS突变的癌症葡萄糖溶解是什么

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