肺癌胸部放射治疗后的心脏毒性
Gerard M Walls1,2, Carmen Bergom3,4, Joshua D Mitchell5
1Department of Radiation Oncology, Washington University in St Louis, Saint Louis, MO, USA. g.walls@qub.ac.uk.
British journal of cancer
|November 7, 2024
概括
肺癌的放射治疗可能会损害心脏,导致20%的患者出现问题. 更好地了解和报告辐射辐射.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 胸部放射瘤学 胸部辐射瘤学
- 医学物理 医学物理
背景情况:
- 放射治疗是不可切除的非小细胞肺癌 (NSCLC) 的标准治疗方法.
- 尽管有进展,胸部放射治疗具有高心脏损伤风险,影响20%的患者.
- 改善存活率需要尽量减少放射治疗 (RT) 引起的心血管疾病.
研究的目的:
- 审查肺癌常规胸部放射治疗中心脏毒性的证据基础.
- 突出目前的数据,未满足的临床需求,以及辐射诱导心脏病的未来研究方向.
- 强调需要对心脏毒性进行全面的表征,考虑到患者的并发症和辐射剂量分配.
主要方法:
- 文献综述综合证据关于肺癌放射治疗中的心脏毒性.
- 专注于当前的数据,临床挑战和未来的科学方向.
- 重点是整合瘤学,物理学和心脏瘤学的观点.
主要成果:
- 心脏并发症 (心律不整,心力衰竭,缺血事件) 在接受RT的肺癌患者中发生在20%的患者中.
- 临床试验中的心脏终点报告不足.
- 基线心血管健康和辐射剂量对心脏毒性风险的影响尚未完全理解.
结论:
- 尽量减少心脏毒性至关重要,因为肺癌患者的生存率有所提高.
- 对心脏终点报告的标准化和对风险因素的进一步研究迫切需要.
- 综合瘤学,物理学和心脏瘤学的综合评估对于管理辐射引起的心脏病至关重要.
相关概念视频
Radiological Investigation III: Pulmonary Angiogram and PET Scan
86
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
86
Pneumothorax-II
120
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
120
Biological Effects of Radiation
15.3K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.3K
Imaging Studies for Cardiovascular System III: X-Ray
147
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
147
Pneumothorax-I
172
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
172
Imaging Studies for Cardiovascular System I:Echocardiography
299
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
299


