合成基因组的设计和工程
Joshua S James1,2, Junbiao Dai3,4, Wei Leong Chew2
1Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Nature reviews. Genetics
|November 7, 2024
概括
合成基因组学使得基因组设计和构造能够用于医学和农业的应用. 本次审查简化了实施合成基因组项目的复杂过程,涵盖设计,建造和应用.
科学领域:
- 合成基因组学 合成基因组学
- 基因组工程是基因组工程.
- 系统生物学 系统生物学
背景情况:
- 合成基因组学旨在设计和构建用于研究和应用的基因组.
- 进步是由DNA合成,组装,传递和编辑技术推动的.
- 人工智能有助于预测功能和指导基因组设计.
研究的目的:
- 提供对合成基因组策略的全面审查.
- 简化合成基因组规模项目的实施.
- 涵盖设计,施工,交付,调试和应用.
主要方法:
- 综合基因组学当前策略的审查.
- 分析DNA合成和编辑方面的进展.
- 整合计算工具,如人工智能,用于基因组设计.
主要成果:
- 识别合成基因组项目翻译的关键挑战.
- 编制基因组设计,构建和传递的方法.
- 概述生物生产,细胞疗法和作物改良方面的潜在应用.
结论:
- 合成基因组学为基础研究和应用工程提供了强大的工具.
- 简化实施对于实现合成基因组的潜力至关重要.
- 这一审查为未来的合成基因组工作提供了路线图.
相关概念视频
Synthetic Biology
4.7K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
4.7K
Genomics
36.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.0K
What is Genetic Engineering?
73.7K
Overview
73.7K
The Central Dogma
20.6K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
20.6K
Genome Annotation and Assembly
18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K
Genome Size and the Evolution of New Genes
7.9K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
7.9K


