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Updated: Jun 8, 2025

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence
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Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence

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增强转录复制冲突的目标是ecDNA阳性癌症

Jun Tang1,2, Natasha E Weiser1,3, Guiping Wang3,4

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|November 7, 2024
PubMed
概括

超染色体DNA (ecDNA) 驱动癌症治疗的抵抗力. 增强转录复制冲突,特别是通过抑制CHK1,可以选择性地消除含有ecDNA的瘤,从而提供一种新的治疗策略.

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