寻求健康的行为和SLE诊断延迟:一个多民族的马来西亚队列研究
Fatimah Zanirah Nordin1, Syahrul Sazliyana Shaharir2, Mohd Shahrir Mohamed Said2
1Department of Internal Medicine, Faculty of Medicine and Health Sciences, Islamic Science University of Malaysia, Nilai, Malaysia.
Lupus
|November 7, 2024
概括
种族差异影响马来西亚的系统性红斑狼 (SLE) 诊断. 印度患者的诊断延迟较长,而中国患者的诊断延迟较短,这凸显了及时识别SLE症状的必要性.
科学领域:
- 风湿病学和免疫学
- 公共卫生和流行病学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 系统性红斑狼 (SLE) 呈现异质的临床表现,可能导致诊断延迟.
- 了解寻求健康的行为和诊断时间表对于改善多民族人口中的患者结果至关重要.
研究的目的:
- 为了确定马来西亚SLE患者中寻求健康的行为模式.
- 确定多民族SLE队列中与诊断延迟相关的因素.
- 调查诊断延迟与低水平疾病活动状态 (LLDAS) 实现之间的关系.
主要方法:
- 从2020年1月到2021年6月,涉及154名SLE患者的横截面研究.
- 通过医疗记录审查和面对面采访收集数据,评估社会人口统计学,疾病特征和症状至诊断间隔.
- 寻求健康的行为分为寻求专业帮助,自我治疗或互联网信息;诊断延迟定义为>6个月.
主要成果:
- 24%的患者经历了诊断延迟,与马来 (28%) 和中国 (10.8%) 患者相比,印度 (42.9%) 患者的诊断延迟率明显高 (p=0.037).
- 皮疹与延迟诊断的趋势有关,而泡的尿液则显示出早期诊断的趋势.
- 中国人是唯一与诊断延迟减少相关的重要因素 (OR 0.30; p=0.037);在寻求健康行为和延迟之间没有发现显著的关联.
结论:
- 马来西亚的SLE诊断时间表存在种族差异,印度患者面临更长的延迟,中国患者更短的延迟.
- 早期的SLE诊断与12个月后实现LLDAS的可能性更高有关.
- 迅速识别最初的SLE症状对于及时诊断和改善疾病管理至关重要.
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