不同代谢性肥胖现象与反流性食道炎的关系:倾向性得分匹配分析
Tao He1,2, Peng Wang1,2, Li-Xia Wang1,2
1Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
BMC endocrine disorders
|November 7, 2024
概括
代谢不健康的肥胖症显著增加了逆流食道炎 (RE) 的风险,肥胖症与肥胖症相关.
科学领域:
- 胃肠病学 胃肠病学
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 肥胖是已知的逆流食道炎 (RE) 的风险因素.
- 在RE发育中代谢状态和肥胖之间的相互作用需要进一步研究.
- 了解代谢性肥胖现象型对于评估RE风险至关重要.
研究的目的:
- 调查不同代谢肥胖现象类型与反流性食道炎 (RE) 风险之间的关联.
- 澄清肥胖和代谢异常对RE风险的独立和联合影响.
主要方法:
- 分析了24368名接受上部胃肠内镜检查的成年人队列.
- 参与者被分为四组:代谢健康的正常体重 (MHNW),代谢健康的肥胖 (MHO),代谢不健康的正常体重 (MUNW) 和代谢不健康的肥胖 (MUO).
- 根据性别和年龄分层的多变量逻辑回归被用于评估表型与RE风险之间的关联.
主要成果:
- 与MHNW组相比,MUNW,MHO和MUO组的RE风险较高.
- 代谢不健康的肥胖 (MUO) 现型在男性和女性中呈现了对RE的最高概率比率.
- 肥胖似乎比单独的代谢障碍对RE风险的影响更大.
结论:
- 代谢障碍和肥胖都与反流性食道炎 (RE) 风险的增加有关.
- 肥胖对RE患病率的贡献可能超过代谢障碍的贡献,这突显了不论代谢健康状况如何,肥胖的重要性.
- 临床策略应针对肥胖和代谢健康,以减轻RE风险.
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