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面部衰老,认知障碍和痴呆的风险是面部衰老,认知障碍和痴呆的风险是面部衰老
Xinming Xu1, Guliyeerke Jigeer1, David Andrew Gunn2
1Department of Nutrition and Food Hygiene, Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Institute of Nutrition, Fudan University, 130 Dongan Road, Shanghai, 200030, China.
Alzheimer's research & therapy
|November 7, 2024
概括
看起来比实际年龄更老的老年人面临着更高的认知衰退和痴呆的风险. 面部衰老可能是这些与年龄有关的疾病的早期指标.
科学领域:
- 老年学是指老年学的学科.
- 神经学 神经学
- 皮肤病学 皮肤病学
背景情况:
- 面部衰老,认知障碍和痴呆症是常见的与年龄有关的疾病.
- 面部感知年龄与未来痴呆风险之间的联系尚未被彻底研究.
研究的目的:
- 检查面部年龄 (主观和客观) 与认知障碍和痴呆症风险之间的关联.
主要方法:
- 利用英国生物库 (UKB) 数据 (195,329名参与者,≥60岁) 了解面部年龄和痴呆风险.
- 中国人口老龄化的就业营养和健康项目 (NHAPC) 数据 (612名参与者,≥56岁) 用于客观地评估面部年龄.
- 应用了考克斯的比例危险模型和回归分析,对潜在的混因素进行了调整.
主要成果:
- 在UKB中,更高的面部年龄与痴呆风险增加1.61倍相关 (HR=1.61,95% CI:1.331.96).
- 在NHAPC中,客观的面部衰老 (纹参数) 与较高的认知障碍概率有关 (例如,乌脚:OR=2.48,95%CI:1.065.78).
结论:
- 先进的面部衰老与认知障碍和痴呆症的风险增加有关.
- 面部衰老可能成为早期检测和老年人认知衰退管理的潜在生物标志物.
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