患有亚托皮性皮肤炎的狗缺乏铁
Carolina Frizzo Ramos1,2, Pavlos G Doulidis1, Nina Polakova1
1Department for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine Vienna, Vienna, Austria.
BMC veterinary research
|November 7, 2024
概括
患有犬性皮肤炎 (CAD) 的狗表现出改变的铁参数和耗尽的铁储量,与症状严重程度的增加相关. 铁的稳态在健康狗和亚托皮狗之间有显著差异,这表明亚临床炎症.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 缺铁与非传染性疾病的不良结果有关.
- 铁的参数很少被评估在狗的健康评估.
- 狗皮炎 (CAD) 是一种常见的疾病,具有潜在的系统性影响.
研究的目的:
- 评估和关联CAD的狗的铁参数.
- 为了比较阿托皮和健康狗之间的铁状况.
- 为了研究铁状况和CAD中的炎症标志物之间的关系.
主要方法:
- 追溯分析34只患有CAD的狗和94只健康对照的血液值和血清.
- 血液学和生物化学参数的比较,包括铁的指数.
- 相关性和回归分析以确定铁参数,临床分数和炎症标志物之间的关联.
主要成果:
- 患有CAD的狗体平均体积 (MCV) 和平均体内血红蛋白 (MCH) 较低,但白细胞数量较高 (中性粒细胞,单细胞).
- 患有CAD的患者表现出C-反应蛋白 (CRP) 和总蛋白的升高,与较低的白蛋白,表明低级炎症.
- 降低铁的状态,以较低的MCV和MCH表示,与较高的临床症状得分 (CADESI-4/PVAS) 相相关.
结论:
- 降低铁的状态与患有CAD的狗的症状负担更大有关.
- 与健康对照对照相比,铁平衡在皮炎狗中显著不同.
- 患有CAD的患者呈现出耗尽的铁储量和亚临床炎症证据.
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