晚期嗅觉球泡在COVID-19中的参与
Francesco Morra1, Matteo Minerva2, Silvia Valeggia3
1Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland.
Chemical senses
|November 7, 2024
概括
COVID-19感染会导致持续的嗅球 (OB) 大小减少,即使在恢复嗅觉的患者中也是如此. 这表明,SARS-CoV-2会长期影响嗅觉结构,而不考虑嗅觉功能障碍.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 嗅觉功能障碍,包括低解臭症,是SARS-CoV-2感染的常见症状.
- 在COVID-19之后的嗅觉路径的晚期形态变化尚未完全理解.
研究的目的:
- 为了评估神经学上无症状的COVID-19患者晚期嗅球 (OB) 成像变化.
- 为了将这些OB变化与感染后的嗅觉功能相关联.
主要方法:
- 83名COVID-19患者和25名健康对照人接受了3T-MRI和嗅觉功能测试 (问卷,嗅探棒).
- 最大OB面积是用高分辨率的冠状T2w图像盲目测量.
- 根据嗅觉功能的恢复,患者被分为子组.
主要成果:
- 与对照组相比,前COVID-19患者的平均最大OB面积显著减少 (6.52 ± 1.11 mm2与7.26 ± 1.17 mm2相比).
- 这种降低观察到,无论持续的低度或恢复的正常度.
- 在COVID-19患者小组中没有发现OB大小的显著差异.
结论:
- SARS-CoV-2 感染与嗅球中期/晚期形态变化有关.
- 这些OB变化发生不论存在或持续的嗅觉功能障碍.
- 需要进一步研究长期的嗅觉衰老以及与神经退行性疾病的潜在联系.
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