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Updated: Jun 20, 2026

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites
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长读和短读目标丰富测序方法的比较和交叉验证,以评估AAV向量集成到宿主基因组中的AAV向量集成

Mark Sheehan1, Steven W Kumpf1, Jessie Qian1

  • 1Global Discovery, Investigative and Translational Sciences, Pfizer Inc, Groton, CT 06340, USA.

Molecular therapy. Methods & clinical development
|November 7, 2024
PubMed
概括

对比短读和长读向丰富测序 (TES) 对于腺相关病毒 (AAV) 基因治疗整合分析. 长期阅读的TES发现了更少的集成地点,但揭示了载体重排,这对于安全评估至关重要.

关键词:
在 AAV AAV AAV 中.这里是TES TES.基因治疗的基因疗法长时间阅读有针对性的丰富测序.病毒整合 病毒整合

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