甲状腺功能障碍,甲状腺功能低下,甲状腺刺激激素和痴呆风险:来自NHANES 2011-2012和门德尔随机化分析的结果
Xixi Sheng1, Jixiang Gao1, Kunfei Chen1
1Department of Neurology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China.
Frontiers in aging neuroscience
|November 7, 2024
概括
甲状腺刺激激素 (TSH) 和自由四甲状腺素 (FT4) 水平与认知功能有非线性关系. 甲状腺疾病会影响痴呆的风险,甲状腺功能障碍可能会降低风险,甲状腺功能障碍会增加风险.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 痴呆症在全球范围内构成了重大的社会和经济负担.
- 目前的痴呆症诊断和治疗方法有限,缺乏因果目标.
- 甲状腺功能障碍越来越被认为是认知能力下降的潜在因素.
研究的目的:
- 为了研究甲状腺疾病,甲状腺刺激激素 (TSH) 和自由四甲氨酸 (FT4) 度和认知功能之间的关系.
- 探索甲状腺功能与痴呆风险之间的潜在因果关系.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 的数据 (2011-2012) 关于认知功能和甲状腺参数.
- 采用加权后勤回归和限制立方线 (RCS) 分析.
- 进行了两样本的门德尔随机化 (MR) 来评估因果关系.
主要成果:
- 在TSH/FT4度和认知表现之间观察到非线性关联,特别是动物流利性测试.
- 低TSH和FT4水平与某些认知改善相关,而特定度范围显示出正或负相关性.
- 核磁共振分析表明,甲状腺功能过高可能会降低痴呆风险,甲状腺功能低下可能会增加它,高TSH可能会增加阿尔茨海默病的风险.
结论:
- 甲状腺功能,特别是TSH和FT4水平,与认知功能和痴呆风险存在复杂的非线性关系.
- 甲状腺功能障碍症与痴呆症风险降低有关,而甲状腺功能障碍症和TSH升高与风险增加有关.
- 在风险人群中评估甲状腺功能对于痴呆症预防和管理策略至关重要.
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