通过使用舌头涂层代谢学来识别TCM湿模式的慢性胃炎的生物标志物

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Zhiyuan You¹, Jialin Zhang¹, Yifeng Xu¹

¹Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of TCM Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.

Journal of inflammation research

|November 7, 2024

概括

研究人员在舌头涂层中确定了特定的脂质代谢物,以检测带有湿图案的慢性胃炎. 这种代谢学方法为这种疾病提供了一个新的诊断模型.

科学领域:

代谢学代谢学代谢学
传统中国医学 (TCM) 是一种
胃肠病学胃肠病学

背景情况:

慢性胃炎是一种普遍的疾病,具有不同的病因.
在TCM中,湿模式与特定的胃肠道症状有关.
确定TCM模式的客观生物标志物对于整合传统和现代医学至关重要.

研究的目的:

开发一种使用舌头涂层代谢物的慢性胃炎和湿模式的诊断模型.
调查代谢途径在这种TCM模式的发病过程中的作用.
确定早期检测和诊断的潜在生物标志物.

主要方法:

一项涉及300名慢性胃炎患者的横截面研究 (200例湿模式,100例非湿模式).
使用GC-TOF-MS和UHPLC-QE-MS进行舌头涂层的代谢分析.
基于ROC曲线和差异生物标志物的诊断模型的开发和外部验证.

主要成果:

在各组之间确定了116种不同的代谢物,脂质是最丰富的.
在内部验证中,一个结合,2.6-胺乙,酸和N-hexadecanoyl pyrrolidine的诊断模型获得了高精度 (94.0%).
外部验证证实了该模型的稳定性,准确率为93.9%.

结论:

脂质和类似脂质的化合物是慢性胃炎和湿模式患者舌头涂层中的关键差异代谢物.
,2.6-diaminoheptanedioic acid和N-hexadecanoyl pyrrolidine显示出作为这种疾病的生物标志物具有前景.
已建立的代谢学模型提供了一个准确和验证的方法来识别带有湿模式的慢性胃炎.

关键词:

生物标志物生物标志物慢性胃炎慢性胃炎潮湿的液图案湿的液图案代谢生物组的代谢生物组舌头上的涂层是舌头上的涂层.

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