在Mamelodiodi的基于多卢特格拉维尔的治疗方案中,与病毒学失败相关的因素
Moloko S Mmatsoku1, Sanele Ngcobo2
1School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Southern African journal of infectious diseases
|November 7, 2024
概括
坚持性和某些患者因素与南非接受诺福维尔-胺和多卢特格拉维尔 (TLD) 治疗的艾滋病毒感染者中未被抑制的病毒载荷有关. 干预措施的重点应该是提高患者的服药量,并解决传统产品的使用问题,以获得更好的治疗结果.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于疗效和成本效益,世卫组织建议在低收入和中等收入国家治疗艾滋病毒时使用含多卢特格拉维尔的疗法.
- 这些疗法比 efavirenz 具有优势,包括更高的抗药性遗传障碍和更少的副作用.
研究的目的:
- 在南非,研究与未被抑制的病毒载荷相关的因素,在携带天诺福维尔-胺和多卢特格拉维尔 (TLD) 的艾滋病毒感染者中.
- 确定影响TLD用户治疗结果的关键人口和行为因素.
主要方法:
- 在Mamelodi地区医院的Ntshembo诊所进行了一项横截面研究.
- 参与者包括18岁以上的个体,他们在TLD上感染艾滋病毒超过6个月,具有抑制和未抑制的病毒载荷.
主要成果:
- 不被抑制的病毒载量与男性性别,较低的教育水平和职业有显著的关联.
- 对抗逆转录病毒治疗的不良坚持和使用传统/草药/宗教产品与更高的未抑制病毒载荷有关.
- 新开始的患者表现出明显较低的病毒载荷抑制率.
结论:
- 坚持抗逆转录病毒治疗对于在TLD患者中实现病毒负载抑制至关重要.
- 针对性干预措施,特别是针对新患者的坚持,以及使用补充产品是必要的,以改善艾滋病毒治疗结果.
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